The Impact of Magnesium Deficiency on Personality Changes

magnesium deficiency and depression

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Magnesium, an essential mineral for optimal health, plays a vital role in numerous physiological processes. Recent scientific findings have revealed intriguing connections between magnesium deficiency and personality changes. This article delves into these research findings, providing an informative and comprehensive understanding of this critical health issue.

The Role of Magnesium in Neurological Functioning

Magnesium is a key component in over 300 biochemical reactions in the human body1. It’s particularly crucial for neurological functioning, contributing significantly to nerve transmission and neuromuscular coordination2.

A study published on ScienceDirect reveals that experimental human magnesium depletion led to personality changes among other symptoms3. Another research piece in the Journal of the American College of Nutrition discusses how imbalances and differences in magnesium utilization could potentially heighten vulnerability to magnesium deficiency4.

Magnesium Deficiency and Personality Changes

Emerging research has begun to link personality changes to magnesium deficiency. These changes can manifest as mood disorders, alterations in sleep patterns, and even increased levels of stress and anxiety5,6.

One study found that symptoms of hypomagnesemia, a severe form of magnesium deficiency, included major personality changes such as treatment-resistant depression, or TRD. The scientists concluded “We hypothesize that – when taken together – there is more than sufficient evidence to implicate inadequate dietary magnesium as the main cause of TRD, and that physicians should prescribe magnesium for TRD. Since inadequate brain magnesium appears to reduce serotonin levels, and since anti-depressants have been shown to have the action of raising brain magnesium, we further hypothesize that magnesium treatment will be found beneficial for nearly all depressives, not only TRD.”7

Another article from the European PMC suggested that in rats, magnesium deficiency corresponded with decreased sleep time, which could potentially influence personality traits8.

The Therapeutic Potential of Magnesium

Addressing magnesium deficiency could have significant therapeutic implications. According to a review on MDPI, diseases linked to magnesium deficiency, like muscle contractions, cramps, numbness, tingling, and personality changes, could be mitigated by correcting the deficiency9.

Furthermore, the book “Magnesium in Human Health and Disease” notes that magnesium deficiency could cause a loss of appetite, nausea, vomiting, personality changes, and even death10. Therefore, maintaining optimal magnesium levels becomes crucial for overall health and wellbeing.

Boosting Magnesium Levels

Given the importance of maintaining adequate magnesium levels, it’s essential to ensure a diet rich in magnesium or consider high-quality supplements. Our magnesium bicarbonate products and our topical magnesium oil are designed to support your body’s magnesium levels efficiently and effectively.

However, always consult with a healthcare professional before beginning any supplement regimen.


The link between magnesium deficiency and personality changes is increasingly being recognized by scientific research. As we continue to understand the multifaceted role of magnesium in our bodies, the importance of maintaining optimal magnesium levels becomes even more apparent.

While our magnesium bicarbonate products and topical magnesium oil can help maintain these levels, they’re not a substitute for a balanced diet and regular medical check-ups. By keeping an eye on our health and staying informed, we can ensure that our bodies receive the nutrients they need to function at their best.


  1. Magnesium: biochemistry, nutrition, detection, and social impact of diseases linked to its deficiency
  2. The role and the effect of magnesium in mental disorders: a systematic review
  3. Experimental human magnesium depletion: I. Clinical observations and blood chemistry alterations
  4. Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review)
  5. Magnesium and depression
  6. Magnesium in neuroses and neuroticism
  7. Magnesium for treatment-resistant depression: a review and hypothesis
  8. Magnesium and stress
  9. Magnesium: biochemistry, nutrition, detection, and social impact of diseases linked to its deficiency
  10. Magnesium in human health and disease

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